VECTORMUNE® ND is a vaccine, using HVT as vector in the genome of which, the “F” gene extracted from a genotype I NDV (D26 strain) has been inserted. The HVT strain used (FC 126), its origin, the low number of passages it has undergone, the “F” insert, the insertion site, the promoter selected to ensure the expression of the F gene are all key elements explaining the uniqueness of this vaccine with most of them patented and proprietary to Ceva Animal Health so that Vectormune® ND is actually unique and cannot be compared to other rHVT-F vaccines.
The “F” (for “fusion”) protein is the epitope present on the surface of NDV, allowing it to attach to and
penetrate inside of targeted cells. One can easily understand that if immunity is built up against “F”,
then NDV can no longer infect cells and create damage, and this probably explains the incredibly high
efficacy of Vectormune® ND. Vaccinated chickens are not only protected against clinical and economical
consequences of the infection, but replication of NDV inside the chicken’s body is also hampered as
indicated by a significant reduction of the shedding of the challenge virus as well as a more limited increase
in antibody titer following infection.
Following several years of investigation work with Vectormune® ND, we do believe that this vaccine is more a revolution than a simple evolution. Vectormune® ND will most probably change the approach of Newcastle disease prevention in the field and soon be considered as a strong tool toward the long-term control of this important poultry disease.